Inhibitory proteasomów

Inhibitory proteasomów – substancje działające unieczynniająco na proteasomy, znajdujące zastosowanie w leczeniu nowotworów. Bortezomib był pierwszym z tej grupy leków dopuszczonym na amerykański rynek farmaceutyczny.

Badano działanie inhibujące proteasomy disulfiramu^[1]^[2]^[3], galusanu epigallokatechiny^[4] i salinosporamidu A.

Przypisy[edytuj | edytuj kod]

↑ H. Lövborg, F. Oberg, L. Rickardson, J. Gullbo i inni. Inhibition of proteasome activity, nuclear factor-KappaB translocation and cell survival by the antialcoholism drug disulfiram.. „Int J Cancer”. 118 (6), s. 1577-80, Mar 2006. DOI: 10.1002/ijc.21534. PMID: 16206267.
↑ M. Wickström, K. Danielsson, L. Rickardson, J. Gullbo i inni. Pharmacological profiling of disulfiram using human tumor cell lines and human tumor cells from patients.. „Biochem Pharmacol”. 73 (1), s. 25-33, Jan 2007. DOI: 10.1016/j.bcp.2006.08.016. PMID: 17026967.
↑ B. Cvek, Z. Dvorak. The value of proteasome inhibition in cancer. Can the old drug, disulfiram, have a bright new future as a novel proteasome inhibitor?. „Drug Discov Today”. 13 (15-16), s. 716-22, Aug 2008. DOI: 10.1016/j.drudis.2008.05.003. PMID: 18579431.
↑ K. Osanai, KR. Landis-Piwowar, QP. Dou, TH. Chan. A para-amino substituent on the D-ring of green tea polyphenol epigallocatechin-3-gallate as a novel proteasome inhibitor and cancer cell apoptosis inducer.. „Bioorg Med Chem”. 15 (15), s. 5076-82, Aug 2007. DOI: 10.1016/j.bmc.2007.05.041. PMID: 17544279.

[1] H. Lövborg, F. Oberg, L. Rickardson, J. Gullbo i inni. Inhibition of proteasome activity, nuclear factor-KappaB translocation and cell survival by the antialcoholism drug disulfiram.. „Int J Cancer”. 118 (6), s. 1577-80, Mar 2006. DOI: 10.1002/ijc.21534. PMID: 16206267.

[2] M. Wickström, K. Danielsson, L. Rickardson, J. Gullbo i inni. Pharmacological profiling of disulfiram using human tumor cell lines and human tumor cells from patients.. „Biochem Pharmacol”. 73 (1), s. 25-33, Jan 2007. DOI: 10.1016/j.bcp.2006.08.016. PMID: 17026967.

[3] B. Cvek, Z. Dvorak. The value of proteasome inhibition in cancer. Can the old drug, disulfiram, have a bright new future as a novel proteasome inhibitor?. „Drug Discov Today”. 13 (15-16), s. 716-22, Aug 2008. DOI: 10.1016/j.drudis.2008.05.003. PMID: 18579431.

[4] K. Osanai, KR. Landis-Piwowar, QP. Dou, TH. Chan. A para-amino substituent on the D-ring of green tea polyphenol epigallocatechin-3-gallate as a novel proteasome inhibitor and cancer cell apoptosis inducer.. „Bioorg Med Chem”. 15 (15), s. 5076-82, Aug 2007. DOI: 10.1016/j.bmc.2007.05.041. PMID: 17544279.

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