Endozepine

Endozepines are endogenous compounds with benzodiazepine like effects. They have been linked to hepatic encephalopathy and have controversially been linked to some cases of recurrent stupor.^[1] Initially, the key diagnostic test is stupor which is sensitive to the benzodiazepine receptor antagonist flumazenil in the absences of exogenous benzodiazepines.

Potential candidates for these compounds are:^[2]

oleamides
nonpeptidic endozepines such as inosine
the protein Diazepam binding inhibitor (DBI)

References[edit]

^ Cortelli, P.; Avallone, R.; Baraldi, M.; Zeneroli, ML.; Mandrioli, J.; Corsi, L.; Riva, R.; Tinuper, P.; et al. (Dec 2005). "Endozepines in recurrent stupor". Sleep Med Rev. 9 (6): 477–87. doi:10.1016/j.smrv.2005.07.003. PMID 16233983.
^ Farzampour, Z; Reimer, RJ; Huguenard, J (2015). "Endozepines". Diversity and Functions of GABA Receptors: A Tribute to Hanns Möhler, Part A. Advances in Pharmacology (San Diego, Calif.). Vol. 72. pp. 147–64. doi:10.1016/bs.apha.2014.10.005. ISBN 9780128026601. PMC 4550098. PMID 25600369.

[Cortelli-2005-1] Cortelli, P.; Avallone, R.; Baraldi, M.; Zeneroli, ML.; Mandrioli, J.; Corsi, L.; Riva, R.; Tinuper, P.; et al. (Dec 2005). "Endozepines in recurrent stupor". Sleep Med Rev. 9 (6): 477–87. doi:10.1016/j.smrv.2005.07.003. PMID 16233983.

[2] Farzampour, Z; Reimer, RJ; Huguenard, J (2015). "Endozepines". Diversity and Functions of GABA Receptors: A Tribute to Hanns Möhler, Part A. Advances in Pharmacology (San Diego, Calif.). Vol. 72. pp. 147–64. doi:10.1016/bs.apha.2014.10.005. ISBN 9780128026601. PMC 4550098. PMID 25600369.

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